Description

The non-toxic Dual Dye:

Brilliant Peel Dual Dye provides retinal surgeons with a non-toxic dye for intense and selective staining of ILM, ERM  and vitreous remnants. Fast sinking, maximised contact surface with tissue due to it’s higher density provides safer peeling due to distinct staining of the membrane.

Composition of one 0.5 ml syringe / vial:
0.125 mg Brilliant Blue G,
0.65 mg Bromphenol Blue,
0.1 ml D2O
0.95 mg Na₂HPO₄ x 2 H₂O
0.15 mg NaH₂PO₄ x 2 H₂O
4.1 mg NaCl
ad 0.5 ml water for injection purposes
Concentration:
0.25 g/l Brilliant Blue G
1.3 g/l Bromphenol Blue
Density:
1.03 g/cm3

Literature
1 Lüke C, et al.: Retinal tolerance to dyes, Br J Ophthalmol, 2005, 89, 1188-1191
2 Haritoglou C, et al.: Färbetechniken in der Makulachirurgie, Ophthalmologe, 2006, 103, 927-934
3 Ueno A, et al.: Biocompatibility of Brilliant Blue G in a rat model of subretinal injection, Retina, 2007, 27, 499-504
4 Enaida H, et al.: Brilliant Blue G selectively stains the internal limiting membrane – Brilliant Blue G assisted membrane peeling, Retina, 2006, 26, 631 – 636
5 Enaida H, et al.: Preclinical investigation of internal limiting membrane staining and peeling using intravitreal Brilliant Blue G, Retina, 2006, 26, 623-630
6 Hisatomi T, et al.: Staining ability and biocompatibility of Brilliant Blue G – preclinical study of Brilliant Blue G as an adjunct for capsular staining, Arch Ophthalmol, 2006, 124, 514-519
7 Goldman JM, et al.: Adjunct devices for managing challenging cases in cataract surgery – capsular staining and ophthalmic viscosurgical devices, Curr Opin Ophthalmol, 2007, 18, 52-57
8 Meyer CH, et al.: Historical considerations in applying vital dyes in vitreoretinal surgery: from early experiments to advanced chromovitrectomy, Expert Rev. Ophthalmol., 2007, 71-77
9 Hiebl W, et al.: Substances for staining biological tissues: use of dyes in ophthalmology, Klin Monatsbl Augenh, 2005, 222, 309-311
10 Frank Schuettauf, Christos Haritoglou, Christian A. May, Robert Rejdak, Anna Mankowska, Wolfgang Freyer, Kirsten Eibl, Eberhart Zrenner, Anselm Kampik and Sebastian Thaler, Administration of Novel Dyes for Intraocular Surgery: An In Vivo Toxicity Animal Study, Invest Ophthalmol Vis Sci. 2006; 47:3573–3578
11 Christos Haritoglou, Ricarda G Schumann, Rupert Strauss, Siegfried G Priglinger, Aljoscha S Neubauer, Anselm Kampik, Vitreoretinal surgery using bromphenol blue as a vital stain: evaluation of staining characteristics in humans, Br J Ophthalmol 2007; 91:1125–1128
12 Rodrigues EB, et al.: Vital dyes for chromovitrectomy, Curr Opin Ophthalmol, 2007 May; 18(3):179-87
13 Furlani BA, et al.: Lutein and zeaxanthin toxicity with and without brilliant blue in rabbits. J Ocul Pharmacol Ther. 2014 Sep; 30(7):559-66. doi: 10.1089/jop.2013.0171. Epub 2014 Jun 5.
14 Tura A, et al.: Testing the effects of the dye acid violet-17 on retinal function for an intraocular application in vitreo-retinal surgery. Graefes Arch Clin Exp Opthalmol. 2014 Dec; 252(12):1927-37. doi: 10.1007/s00417-014-2761-9. Epub 2014 Sep 14.
15 Patent DE102012103097 A1
16 Sousa-Martins D, et al.: Use of lutein and zeaxanthin alone or combined with Brilliant Blue to identify intraocular structures intraoperatively. Retina. 2012 Jul; 32(7):1328-36. doi: 10.1097/IAE.0b013e318239e2b6.